Side effects, also called adverse reactions, are unwanted and undesirable effects that may be related to a drug. These side effects can range from minor reactions such as nausea, headaches, and upset stomachs to more life-threatening ones like anaphylaxis or liver damage.

All drugs approved by the Philippine Food and Drug Administration (FDA) are deemed safe and effective. Similarly, vitamins and food supplements also need to be safe in order to be approved for sale. However, no drug or supplement is 100% safe; the possibility of experiencing side effects is always there.

When do side effects usually happen?

Side effects are usually experienced when one is starting on a new medication or supplement or when someone abruptly stops taking certain medications, such as withdrawal symptoms experienced by people taking blood pressure or anxiety medications. They can also occur when adjusting the dose to a lower or higher one.

The occurrence and severity of side effects can also vary from person to person. Factors like age, gender, genetics, use of other medications, vitamins, or supplements, and underlying diseases such as a weakened immune system or conditions affecting kidney and liver functions can affect how one responds to certain medications.

What is Pynocare?

Pynocare is an FDA-approved medication for the treatment of melasma. It is a combination of procyanidin (as French Maritime Pine bark extract), vitamins A (as D. Salina extract), C, and E.

Procyanidin has demonstrated both antioxidant and anti-inflammatory properties that can greatly help in disrupting the pathways involved in the pathogenesis of melasma. It is also a powerful antioxidant and has been shown to be more potent than vitamins C and E in fighting oxidative stress. In addition, it also helps recycle vitamin C and regenerate vitamin E in the body, improving their antioxidant activities. On top of all that, procyanidin has been shown to protect the natural antioxidants in the body.

Pynocare has been clinically proven to reduce the appearance of melasma patches with 8 to 12 weeks of use. Its recommended dosage is 1 tablet twice a day throughout the duration of the treatment. It can also be used as a preventive measure for melasma, with a recommended dosage of 1 tablet once a day.

Side effects of taking Pynocare

What are the side effects of taking Pynocare? Learn more about the clinically proven solution for melasma here.

As mentioned, all drugs, vitamins, and supplements can have side effects, including Pynocare. Studies conducted with Pynocare have noted very minimal side effects. Below are some of the side effects of taking Pynocare that you might experience.

A study in Malaysia was conducted to test the efficacy of French Maritime Pine Bark (FMPB) extract containing procyanidins on thirty women with melasma. They were divided into two groups: one receiving the placebo and the other receiving the treatment. They received 40 mg of FMPB extract twice daily for 30 days. The treatment group showed significant improvement in the degree of lightening of the skin following the one-month period of treatment when compared to the placebo group.

• Fatigue: In terms of side effects, only 6.67% of the treatment group in the study mentioned above experienced
• Headache: In the same study, 33% of the treatment group experienced headaches.
• Dizziness: Similarly, 3.33% of the treatment group also experienced dizziness at one point in the
• Diarrhea: 33% of the treatment group also experienced diarrhea during the study.

The severity of these side effects was minor and tolerable, as evident by the fact that none of the participants in the treatment group backed out during the study. A complete blood count, liver function tests, kidney profile, abdominal ultrasound, and electrocardiogram were also tested prior to and after the study. No changes occurred in these parameters throughout the study.

Another study was conducted in the Philippines to assess the safety and efficacy of oral procyanidin with vitamins A, C, and E among Filipinos with melasma. A total of 60 women with melasma participated in the study and were divided into two groups: 30 in the placebo group and 30 in the treatment group. Each of the test drugs contained 24 mg of procyanidin, 6 mg of beta-carotene (vitamin A), 60 mg of ascorbic acid (vitamin C), and 15 IU of d-alpha-tocopheryl acetate (vitamin E) and were given 1 tablet twice daily for 8 weeks.

The study found significant improvement in the appearance of melasma for those in the treatment group compared to those in the placebo group.

• Development of metallic taste: In terms of side effects, none of the side effects experienced by the participants of the study in Malaysia were noted. However, one of the participants in the treatment group dropped out of the study due to the development of a metallic taste. The development of such a side effect may be a sign of an allergic reaction to the Other drugs, such as antibiotics, are known to produce this type of side effect.

Overall, the studies surrounding Pynocare suggest that side effects are very minimal and very minor. They are generally tolerable and manageable. However, if you happen to be taking Pynocare for melasma treatment and experience any of these symptoms or any other symptoms that are out of the ordinary, make sure to inform your physician or seek medical help.

Reducing the risk of the side effects of taking Pynocare

As mentioned, side effects are always a possibility with any medication. But this doesn’t mean that you can’t lower your risk of experiencing them. There are several ways that you can learn about possible side effects and reduce the risk of getting them.

• Consult your physician: It is no question by now that self-diagnosis and self-medication do more harm than good. Make sure to consult your physician before taking any medications. They can also inform you of any side effects that you can expect with your treatment and ways to manage them. Make sure to mention any other conditions you have or if you are taking any other medications so that they can better tailor their treatment to your
• Talk to your pharmacist: Pharmacists are considered drug experts and certainly know a great deal about medicines. If you have questions about how to properly take your medications, they are your friends. They can also guide you on how to time your medications to avoid drug interactions, especially when taking more than one
• Follow medication instructions: Make sure to always check the label of your medications and read the instructions, especially on how to properly store Make sure to also follow the proper way to take them as directed by your physician.

Reporting side effects

Reporting the side effects that you experience from certain medications does not end with reporting them to your physician. The Philippine FDA also encourages patients to report their side effects; this way, both the FDA and the drug companies that own the products can have data on how to improve their products. You can read more about this at https://www.fda.gov.ph/pharmacovigilance-reportingpatient/ or report through https://primaryreporting.who-umc.org/PH.

References

• Handog, E.B., Galang, D.A.V.F., De Leon-Godinez, M.A., & Chan, G.P. (2009). A randomized, double-blind, placebo-controlled trial of oral procyanidin with vitamins A, C, E for melasma among Filipino women. International Journal of Dermatology, (48), pp. 896-901. https://doi.org/10.1111/j.1365-4632.2009.04130.x
• US FDA. Finding and Learning about Side Effects (adverse reactions). From https://www.fda.gov/drugs/information-consumers-and-patients-drugs/finding-and-learning-about-s ide-effects-adverse-reactions
• Shahrir, M., Saadiah, S., Ismail, S., et al. (2004). The efficacy and safety of French Maritime Pine Bark Extract in the form of MSSC complex actisome on melasma. International Medical Journal. http://www.e-imj.com/Vol3-No2/Vol3-No2-B6.htm

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PYNOCARE (Procyanidin + Ascorbic Acid + Betacarotene + d-Alpha-Tocopheryl Acetate)

The first and only oral medicine that is clinically proven to reduce Melasma or dark spots formation in just 8 weeks. Unlike creams, lotions, and gels, it has MSCC or Melasma Skin Clear Complexion Complex formulation that deeply penetrates the inner layers of the skin, to help normalize melanin levels, thus minimizing the appearance of dark spots in a short time.

Mega We Care

Mega Lifesciences Limited Inc. or Mega We Care, is actively involved in helping millions of people have access to safe, effective, world-class quality nutritional & herbal supplements, OTC, and ethical products.