For many, melasma patches and uneven skin tone can be sources of frustration and self-consciousness. We go far and beyond in search of the perfect product, the best skincare routine, and the most ideal supplements to use. We are always on the lookout for new and innovative products – like the new Pynocare Melasma Cream. That’s right! The trusted and  clinically-proven solution for melasma is now in cream form to give you that holistic approach to dealing with melasma.

Innovative Melasma Cream: A Formulation Breakdown

The new Pynocare Melasma Cream is a revolutionary skincare product designed to combat melasma with a powerful blend of scientifically-backed ingredients. Let’s take a look at how each ingredient works synergistically to lighten melasma and promote healthier, more radiant skin.

Tyrosinase Inhibitors

Tyrosinase is an enzyme that catalyzes the first two steps in the melanin production pathway. Specifically, it converts the amino acid tyrosine into dopaquinone, which is a precursor to melanin. When tyrosinase activity is elevated, it leads to increased melanin production, contributing to hyperpigmentation conditions like melasma. Topical tyrosinase inhibitors block the activity of this enzyme, thereby reducing melanin synthesis.

Commonly used inhibitors include hydroquinone, kojic acid, and n-butyl resorcinol, which not only help lighten existing melasma but also prevent its recurrence. Additionally, when combined with other beneficial ingredients like antioxidants, they can enhance overall skin health while being gentle enough for sensitive skin types.

1. Kojic Acid

Kojic acid is a well-known skin brightening agent derived mainly from the fungi Aspergillus oryzae. It works by inhibiting the enzyme tyrosinase, which is crucial in melanin production. By reducing melanin synthesis, kojic acid effectively lightens existing pigmentation and helps prevent the formation of new dark spots.

2. N-Butyl Resorcinol

N-butyl resorcinol is a relatively newer addition to the family of topical agents used for skin lightening and the treatment of hyperpigmentation. Several studies have been conducted attesting to its safety and efficacy. One study in 2013 show that n-butylresorcinol exceeded the potency of hydroquinone, arbutin, and kojic acid. The resulting clinical improvement of skin hyperpigmentations shows that it is a very valuable active compound for the management of pigmentation disorders.

3. Resveratrol

Resveratrol has been around for years and it’s for a good reason. A natural antioxidant found in grapes and berries, resveratrol not only protects the skin from oxidative stress but also possesses skin-brightening properties. It also helps reduce inflammation and enhance the overall appearance of the skin, making it a valuable addition to the Pynocare Melasma Cream.

ROS Scavengers / Reduction Agents

Reactive oxygen species (ROS) are highly reactive molecules that contain oxygen and can easily interact with other molecules in the body. They include free radicals such as superoxide and hydroxyl radicals, as well as non-radical species like hydrogen peroxide. Elevated levels of ROS can stimulate melanogenesis leading to increased pigmentation.

1. Vitamin E

Known for its moisturizing and healing properties, vitamin E is essential for maintaining skin health. It helps soothe irritated skin and protects against environmental damage, creating a more resilient skin barrier. It also aids in the skin’s repair processes, contributing to a more even skin tone over time.

2. Tetrahydrocurcumin

Tetrahydrocurcumin is a bioactive metabolite of curcumin, the active compound found in turmeric. Known for its strong antioxidant properties, it effectively scavenges ROS, helping to mitigate oxidative stress in the skin and reducing the stimulation of melanogenesis. In addition to its ROS scavenging activity, it also possesses anti-inflammatory properties that can soothe irritated skin, making it an ideal addition to a melasma cream.

Inflammation-induced Melanogenic Response Inhibitor

Inflammation plays a significant role in the pathogenesis of melasma. Factors, including UV radiation, hormonal changes, and environmental stressors, can trigger inflammatory responses in the skin. This inflammation leads to the release of pro-inflammatory cytokines and other mediators that stimulate melanocytes.

1. Glycyrrhiza Glabra Extract (Licorice Extract)

Glycyrrhiza glabra, commonly known as licorice, is a plant renowned for its medicinal properties and is widely used in traditional medicine. The extract from this plant, particularly its active component glabridin, has gained attention in dermatology for its ability to inhibit melanin synthesis.

Tyrosinase Degrader and Skin Turnover Accelerator

            Tyrosinase degraders, such as linoleic acid, work by promoting the degradation of the tyrosinase enzyme rather than merely inhibiting its activity. On the other hand, skin turnover refers to the natural process by which old skin cells are shed and replaced by new ones. This process is vital for maintaining healthy skin and can be particularly beneficial in treating hyperpigmentation.

1. Linoleic Acid

Linoleic acid is both a tyrosinase degrader and skin turnover accelerator. As an essential fatty acid, linoleic acid also plays a crucial role in maintaining skin hydration and barrier function. Unlike traditional tyrosinase inhibitors that work by blocking the enzyme’s activity, linoleic acid promotes the degradation of tyrosinase itself.

Linoleic acid also plays a significant role in enhancing skin cell turnover. It supports the natural exfoliation process by promoting the shedding of dead skin cells and encouraging the growth of new, healthy cells.

Melanosome Transfer Inhibitors

Melanosome transfer inhibitors work by blocking the pathways that facilitate the movement of melanosomes from melanocytes to keratinocytes. This inhibition can occur at various stages, including the release of melanosomes from melanocytes and their uptake by keratinocytes. This disruption leads to the reduction of melanin deposits in the upper layer of the skin.

1. Niacinamide

This versatile form of vitamin B3 has gained significant attention in the skincare industry due to its numerous benefits for skin health. Among its various properties, niacinamide functions as a melanosome transfer inhibitor, making it particularly vital for a melasma cream to have. With its gentle nature and well-documented efficacy, niacinamide is an excellent choice for individuals seeking to achieve a more even skin tone and improve overall skin health.

Why Choose Pynocare Melasma Cream?

Aside from Pynocare being a trusted brand when it comes to melasma treatment, the new Melasma Cream stands out in the crowded market of skincare products due to its scientifically formulated blend of ingredients that target melasma from multiple angles. The unique combination of potent skin-lightening agents and nourishing components not only addresses existing pigmentation but also helps prevent future occurrences.

Moreover, Pynocare Melasma Cream is formulated with convenience in mind. It is suitable for daily use, making it a must-have addition to your melasma treatment regimen. Its lightweight texture absorbs quickly, allowing for easy layering with other products, and is suitable for various skin types, including sensitive skin. Still not convinced? Let’s take a closer look at the data!

Pynocare Melasma Cream Clinical Data

            Not only does the new Pynocare Melasma Cream boast a blend of scientifically-proven ingredients, it is also backed by real-world clinical data as proof of its safety and efficacy.

Pynocare Melasma Cream was evaluated in a study involving 36 Indian females 30 to 45 years old.

1. Subject Self Evaluation

The self-evaluation data shows that 80% of the participants agree that the product helped reduce their melasma and 94% agreed that the product helped in skin brightening after 28 days of treatment. In addition 100% of them agreed that the product did not cause itching, irritation, or burning sensation on the skin at any point of the treatment.

2. Dermatological Evaluation

Statistical analysis of the study data shows a significant decrease in mMASI Score (reduction in melasma area) by -.9.72% at 28 days after application of tested product. Dermatological evaluation also shows no occurrence of erythema, oedema, dryness, scaling, peeling, itching, and tingling after 28 days of application.

3. Mexametry

Data also shows a significant decrease in the melanin content shows a lightening effect of the product on the Melasma spot. Mexametry uses a mexameter, which employs a specific wavelength of light to analyze the skin’s color. The device measures the absorption and reflection of light by the skin, allowing for the quantification of various chromatic parameters.

4. Chromametry

The statistical analysis of the study data shows a significant increase in L* parameter by +1.90% & +3.53% on the cheek bone. The L* parameter represents the lightness of a color, ranging from 0 to 100. A value of 0 indicates complete darkness (black), while a value of 100 represents maximum brightness (white). This scale allows for the quantification of how light or dark a color appears.

Conclusion

Pynocare Melasma Cream offers an effective solution for those struggling with melasma. By leveraging the power of its carefully selected ingredients, this cream not only lightens existing dark patches but also nurtures the skin, promoting overall radiance. Embrace the journey to melasma-free and radiant skin with Pynocare Melasma Cream, and let your natural beauty shine through!

Disclaimer

The information presented in this article is based on published scientific data and research findings. While every effort has been made to ensure the accuracy and reliability of the information provided, it is important to note that this content is intended for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment. Never disregard professional medical advice or delay in seeking it because of something you have read in this article.

References

Chang, Y., Lee, T. L., Oyerinde, O., Desai, S. R., Aljabban, A., Bay, C. P., Bain, P. A., & Chung, H. J. (2022). Efficacy and safety of topical agents in the treatment of melasma: What’s evidence? A systematic review and meta‐analysis. Journal of Cosmetic Dermatology, 22(4), 1168–1176. https://doi.org/10.1111/jocd.15566

Nayak, C. S., Ansari, S. M. M., Salve, V., & Patil, S. (2019). Effectiveness of a combination of anti-pigmentary products in facial post-inflammatory hyperpigmentation. International Journal of Research in Dermatology, 6(1), 1. https://doi.org/10.18203/issn.2455-4529.intjresdermatol20195199

Resende, D. I. S. P., Ferreira, M. S., Lobo, J. M. S., Sousa, E., & Almeida, I. F. (2022). Skin Depigmenting Agents in Anti-Aging Cosmetics: A Medicinal Perspective on Emerging ingredients. Applied Sciences, 12(2), 775. https://doi.org/10.3390/app12020775

Kolbe, L., Mann, T., Gerwat, W., Batzer, J., Ahlheit, S., Scherner, C., Wenck, H., & Stäb, F. (2012). 4‐n‐butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. Journal of the European Academy of Dermatology and Venereology, 27(s1), 19–23. https://doi.org/10.1111/jdv.12051

Jaffri, J. M. (2023). Reactive oxygen species and antioxidant system in selected skin disorders. Malaysian Journal of Medical Sciences, 30(1), 7–20. https://doi.org/10.21315/mjms2023.30.1.2

PYNOCARE (Procyanidin + Ascorbic Acid + Betacarotene + d-Alpha-Tocopheryl Acetate)

The first and only oral medicine that is clinically proven to reduce Melasma or dark spots formation in just 8 weeks. Unlike creams, lotions, and gels, it has MSCC or Melasma Skin Clear Complexion Complex formulation that deeply penetrates the inner layers of the skin, to help normalize melanin levels, thus minimizing the appearance of dark spots in a short time.

Mega We Care

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